CLUSTAL 2.0.12 multiple sequence alignment EF424621_AntelopeCoV_US/OH1/20 ---MSKINKYGLELHWAPEFPWMFEDAEEKLDNPSSSEVDIVCSTTAQKL 47 EF424622_GiCoV_US/OH3-TC/2006_ ---MSKINKYGLELHWAPEFPWMFEDAEEKLDNPSSSEVDIVCSTTAQKL 47 NC_003045_BCoV_BCoV-ENT_nsp1_2 ---MSKINKYGLELHWAPEFPWMFEDAEEKLDNPSSSEVDIVCSTTAQKL 47 NC_007732_PHEV_VW572_nsp1_211. ---MSKINKYGLELYWAPEFPWMFEDAEEKLDNPSSSEVDIVCSTTAQKL 47 NC_005147_HCoV-OC43_OC43_nsp1_ ---MSKINKYGLELHWAPEFPWMFEDAEEKLDNPSSSEVDMICSTTAQKL 47 NC_001846_MHV_MHV-A59_nsp1_210 ---MAKMGKYGLGFKWAPEFPWMLPNASEKLGNPERSEEDGFCPSAAQEP 47 NC_006577_CoV-HKU1A_N1_nsp1_20 ---MIKTSKYGLGFKWAPEFRWLLPDAAEELASPMKSDEGGLCPSTGQAM 47 AY884001_CoV-HKU1B_N2_nsp1_200 ---MIKTSKYGLGFKWAPEFRWLLPDAAEELASPMKSDEGGLCPSTGQAM 47 DQ339101_CoV-HKU1C_N5_nsp1_200 ---MIKTSKYGLGFKWAPEFRWLLPDAAEELASPMKSDEGGLCPSTGQAM 47 NC_004718_SARS-human_Tor2_nsp1 ---------------MESLVLGVNEKTHVQLSLPVLQVRDVLVRG--FGD 33 AY545919_SARS-badger_CFB/SZ/94 ---------------MESLVLGVNEKTHVQLSLPVLQVRDVLVRG--FGD 33 AY304488_SARS-civet_SZ16_nsp1_ ---------------MESLVLGVNEKTHVQLSLPVLQVRDVLVRG--FGD 33 NC_009694_SARS-bat_HKU3-1_nsp1 ---------------MESLVLGVNEKTHVQLSLPVLQVRDVLVRG--FGD 33 NC_009019_Bat-CoV-HKU4_B04f MLSKASVTTQGARGKYRAELYNEKRSDHVACTVPLCDTDDMACKLTPWFE 50 NC_009020_Bat-CoV-HKU5_LMH3f MSFVAGVAPQGARGKYRAELNTEKRTDHVSLKASLCDAGDLVLKISPWFM 50 NC_002645_HCoV-229E_inf-1_nsp1 ---------------------------MACNRVTLAVASDSEISANGCST 23 NC_005831_HCoV-NL63_AmsterdamI ---------------------------MFYNQVTLAVASDSEISGFGFAI 23 NC_003436_PEDV_CV777_nsp1_297. ---------------------------MASNHVTLAFANDAEISAFGFCT 23 NC_009657_BtCoV-G1_BtCoV/512/2 ---------------------------MASNHISLAFANDEEISAIGFGS 23 EF203064_Bat-CoV-HKU2_HKU2/GD/ ---------------------------MSINQLTLAVASDQEISAHGYPT 23 NC_002306_TGEV_PUR46-MAD_nsp1_ ---------------------------MSSKQFKILVNEDYQVNVPSLP- 22 DQ811787_PRCV_ISU-1_nsp1_304.. ---------------------------MSSKQFKILVNEDYQVNVPSLP- 22 AY994055_FIPV_79-1146_nsp1_311 ---------------------------MSSKQFKILVNEDYQVNVPSLP- 22 NC_009021_Bat-CoV-HKU9_BF_005I ---------------MEGVPDPPKLKSMVVTTLKWCDPFAN-PNVTGWDI 34 EF424621_AntelopeCoV_US/OH1/20 ETGGICPENHVMVDCRRLLKQECCVQSSLIREIVMNTRPYDLEVLLQDAL 97 EF424622_GiCoV_US/OH3-TC/2006_ ETGGICPENHVMVDCRRLLKQECCVQSSLIREIVMNTRPYDLEVLLQDAL 97 NC_003045_BCoV_BCoV-ENT_nsp1_2 ETGGICPENHVMVDCRRLLKQECCVQSSLIREIVMNTRPYDLEVLLQDAL 97 NC_007732_PHEV_VW572_nsp1_211. ETGGICPENHVMVDCRRLLKQECCVQSSLIREIVMNTRPYDLEVLLQDAL 97 NC_005147_HCoV-OC43_OC43_nsp1_ ETDGICPENHVMVDCRRLLKQECCVQSSLIREIVMNASPYDLEVLLQDAL 97 NC_001846_MHV_MHV-A59_nsp1_210 KVKGKTLVNHVRVNCSRLPALECCVQSAIIRDIFVDEDPQKVEASTMMAL 97 NC_006577_CoV-HKU1A_N1_nsp1_20 ESVGFVYDNHVKIDCRCILGQEWHVQSNLIRDIFVHEDLHVVEVLTKTAV 97 AY884001_CoV-HKU1B_N2_nsp1_200 ESVGFVYDNHVKIDCRCILGQEWHVQSNLIRDIFVHEDLHVVEVLTKTAV 97 DQ339101_CoV-HKU1C_N5_nsp1_200 ESVGFVYDNHVKIDCRCILGQEWHVQSNLIRDIFVHEDLHVVEVLTKTAV 97 NC_004718_SARS-human_Tor2_nsp1 SVEEALSEAREHLKNG--TCGLVELEKGVLPQLEQP------YVFIKRSD 75 AY545919_SARS-badger_CFB/SZ/94 SVEEALSEAREHLKNG--TCGLVELEKGVLPQLEQP------YVFIKRSD 75 AY304488_SARS-civet_SZ16_nsp1_ SVEEALSEAREHLKNG--TCGLVELEKGVLPQLEQP------YVFIKRSD 75 NC_009694_SARS-bat_HKU3-1_nsp1 SVEEALSEAREHLKNG--TCGLVELEKGVLPQLEQP------YVFIKRSD 75 NC_009019_Bat-CoV-HKU4_B04f DGETAFNQVSSILKEKGKILFVPMHMQRAMKFLPGP------RVYLVERL 94 NC_009020_Bat-CoV-HKU5_LMH3f DGESAYKHVSEQLSKGSKLLFVPQTLKGFIRHLPGP------RVYLVERL 94 NC_002645_HCoV-229E_inf-1_nsp1 IAQAVRRYSEAASNGFRACRFVSLDLQDCIVGIADD-------------- 59 NC_005831_HCoV-NL63_AmsterdamI PSVAVRTYSEAAAQGFQACRFVAFGLQDCVTGINDD-------------- 59 NC_003436_PEDV_CV777_nsp1_297. ASEAVSYYSEAAASGFMQCRFVSLDLADTVEGLLPE-------------- 59 NC_009657_BtCoV-G1_BtCoV/512/2 VEEAVSYYSDAAVNGFDQCRFVSLGLQDAVVGVEDD-------------- 59 EF203064_Bat-CoV-HKU2_HKU2/GD/ MSDAVEHFSSSASHGFKDCRFVASGLQDIVIGVEPS-------------- 59 NC_002306_TGEV_PUR46-MAD_nsp1_ IRDVLQEIKYCYRNGFEGYVFVPEYCRDLVDCDRKD-------------- 58 DQ811787_PRCV_ISU-1_nsp1_304.. IRDVLQEIKYCYRNGFEGYVFVPEYCRDLVDCDRKD-------------- 58 AY994055_FIPV_79-1146_nsp1_311 FRDALQEIKYCYRNGFDGYVFVPEYRRDLVDCNRKD-------------- 58 NC_009021_Bat-CoV-HKU9_BF_005I PIEEALEYAKQQLRTPEPQLVFVPYYLSHAPGISGD------RVVITDSI 78 EF424621_AntelopeCoV_US/OH1/20 QSREAVLVTPPLGMSLEACYVRGCNPNGWTMGLFRRRSVCNTGRCAVNKH 147 EF424622_GiCoV_US/OH3-TC/2006_ QSREAVLVTPPLGMSLEACYVRGCNPNGWTMGLFRRRSVCNTGRCAVNKH 147 NC_003045_BCoV_BCoV-ENT_nsp1_2 QSREAVLVTPPLGMSLEACYVRGCNPNGWTMGLFRRRSVCNTGRCAVNKH 147 NC_007732_PHEV_VW572_nsp1_211. QSREAVLVTPPLGMSLEACYVRGCNPNGWTMGLFRRRSVCNTGRCAVNKH 147 NC_005147_HCoV-OC43_OC43_nsp1_ QSREAVLVTTPLGMSLEACYVRGCNPKGWTMGLFRRRSVCNTGRCTVNKH 147 NC_001846_MHV_MHV-A59_nsp1_210 QFGSAVLVKPSKRLSIQAWTNLGVLPKTAAMGLFKRVCLCNTRECSCDAH 147 NC_006577_CoV-HKU1A_N1_nsp1_20 KSGTAILIKSP-------LHSLGGFPKGYVMGLFR--------SYKTKRY 132 AY884001_CoV-HKU1B_N2_nsp1_200 KSGTAILIKSP-------LHSLGGFPKGYVMGLFR--------SYKTKRY 132 DQ339101_CoV-HKU1C_N5_nsp1_200 KSGTAILIKSP-------LHSLGGFPKGYVMGLFR--------SYKTKRY 132 NC_004718_SARS-human_Tor2_nsp1 ALSTN-----------------------------------------HGHK 84 AY545919_SARS-badger_CFB/SZ/94 ALSTN-----------------------------------------HGHK 84 AY304488_SARS-civet_SZ16_nsp1_ ALSTN-----------------------------------------HGHK 84 NC_009694_SARS-bat_HKU3-1_nsp1 ALSTN-----------------------------------------HGHK 84 NC_009019_Bat-CoV-HKU4_B04f TGGML-----------------------------------------SKHF 103 NC_009020_Bat-CoV-HKU5_LMH3f TGGTY-----------------------------------------SDPF 103 NC_002645_HCoV-229E_inf-1_nsp1 -------------------------------------------------T 60 NC_005831_HCoV-NL63_AmsterdamI -------------------------------------------------D 60 NC_003436_PEDV_CV777_nsp1_297. -------------------------------------------------D 60 NC_009657_BtCoV-G1_BtCoV/512/2 -------------------------------------------------D 60 EF203064_Bat-CoV-HKU2_HKU2/GD/ -------------------------------------------------D 60 NC_002306_TGEV_PUR46-MAD_nsp1_ -------------------------------------------------H 59 DQ811787_PRCV_ISU-1_nsp1_304.. -------------------------------------------------H 59 AY994055_FIPV_79-1146_nsp1_311 -------------------------------------------------H 59 NC_009021_Bat-CoV-HKU9_BF_005I WYATN--------------------------------------------- 83 EF424621_AntelopeCoV_US/OH1/20 VAYQLYMIDPAGVCFGAGQFVGWVIPLAFMPV-QSRKFIVPWVMYLRKCG 196 EF424622_GiCoV_US/OH3-TC/2006_ VAYQLYMIDPAGVCFGAGQFVGWVIPLAFMPV-QSRKFIVPWVMYLRKCG 196 NC_003045_BCoV_BCoV-ENT_nsp1_2 VAYQLYMIDPAGVCFGAGQFVGWVIPLAFMPV-QSRKFIVPWVMYLRKCG 196 NC_007732_PHEV_VW572_nsp1_211. VAYQLYMIDPAGVCFGAGQFVGWVIPLAFMPA-QSRKFIVPWVMYLRKCG 196 NC_005147_HCoV-OC43_OC43_nsp1_ VAYQLYMIDPAGVCLGAGQFVGWVIPLAFMPV-QSRKFIVPWVMYLRKRG 196 NC_001846_MHV_MHV-A59_nsp1_210 VAFHLFTVQPDGVCLGNGRFIGWFVPVTAIPE-YAKQWLQPWSILLRKGG 196 NC_006577_CoV-HKU1A_N1_nsp1_20 VVHHLSMTTST-TNFG-EDFLGWIVPFGFMPS-YVHKWFQFCRLYIEE-- 177 AY884001_CoV-HKU1B_N2_nsp1_200 VVHHLSMTTST-TNFG-EDFLGWIVPFGFMPS-YVHKWFQFCRLYIEE-- 177 DQ339101_CoV-HKU1C_N5_nsp1_200 VVHHLSMTTST-TNFG-EDFFGWIVPFGFMPS-YVHKWFQFCRLYIEE-- 177 NC_004718_SARS-human_Tor2_nsp1 VVELVAEMDGIQYGRSGITL------GVLVPH-VGETPIAYRNVLLRKNG 127 AY545919_SARS-badger_CFB/SZ/94 VVELVAEMDGIQYGRSGITL------GVLVPH-VGETPIAYRNVLLRKNG 127 AY304488_SARS-civet_SZ16_nsp1_ VVELVAEMDGIQYGRSGITL------GVLVPH-VGETPIAYRNVLLRKNG 127 NC_009694_SARS-bat_HKU3-1_nsp1 VVELVAELDGIQFGRSGITL------GVLVPH-VGETPIAYRNVLLRKNG 127 NC_009019_Bat-CoV-HKU4_B04f LVNQLAYKDQVGAAMMRTTLNAKPL-GMFFPY-DSSLETGEYTFLLRKN- 150 NC_009020_Bat-CoV-HKU5_LMH3f MVNQLAYQNAAGEGVIGTTLQGKRV-GMFFPF-DADLVTGEFQFLLRKK- 150 NC_002645_HCoV-229E_inf-1_nsp1 YVMGLHGNQTLFCNIMKFSDRPFMLHGWLVFS-NSNYLLEEFDVVFGKRG 109 NC_005831_HCoV-NL63_AmsterdamI YVIALTGTNQLCAKILPFSDRPLNLRGWLIFS-NSNYVLQDFDVVFG-HG 108 NC_003436_PEDV_CV777_nsp1_297. YVMVVIGTTKLSAYVDTFGSRPRNICGWLLFS-NCNYFLEELELTFGRRG 109 NC_009657_BtCoV-G1_BtCoV/512/2 VVMLITGVTQLRAYLGTFGDRPLNLRGWLLFS-NCNYFLEELDLVFGRCG 109 EF203064_Bat-CoV-HKU2_HKU2/GD/ FVVALEGDEILTAYIATFGARPRCLRGWLIPS-NSNYVLEEFHVIFGKRG 109 NC_002306_TGEV_PUR46-MAD_nsp1_ YVIGVLGNGVSDLKPVLLTEPSVMLQGFIVRA-NCNGVLEDFDLKIARTG 108 DQ811787_PRCV_ISU-1_nsp1_304.. YVIGVLGNGVSNLKPVLLTEPSVMLQGFIVRS-NCNGVLEDFDFKIARTG 108 AY994055_FIPV_79-1146_nsp1_311 YVIGVLGNGISDLKPVLLTEPSVMLQGFIVRA-NCNGVLEDFDLKFARTG 108 NC_009021_Bat-CoV-HKU9_BF_005I --FGWQPIRELAMDKDGVRYGRGGTHGVLLPMQDPSFIMGDIDIQIRKYG 131 . . : EF424621_AntelopeCoV_US/OH1/20 EKGAYNKDHKRGGFEH-VYNFKVEDAYDLVHDEPKGKFS-KKAYALIRGY 244 EF424622_GiCoV_US/OH3-TC/2006_ EKGAYNKDHKRGGFEH-VYNFKVEDAYDLVHDEPKGKFS-KKAYALIRGY 244 NC_003045_BCoV_BCoV-ENT_nsp1_2 EKGAYNKDHKRGGFEH-VYNFKVEDAYDLVHDEPKGKFS-KKAYALIRGY 244 NC_007732_PHEV_VW572_nsp1_211. DKGAYNKDHKRGGFEH-VYNFKVEDAYDQVHDEPKGKFS-RKAYALLRGY 244 NC_005147_HCoV-OC43_OC43_nsp1_ EKGAYNKDHGRGGFGH-VYDFKVEDAYDQVHDEPKGKFS-KKAYALIRGY 244 NC_001846_MHV_MHV-A59_nsp1_210 NKGSVTSGHFRRAVTMPVYDFNVEDACEEVHLNPKGKYS-CKAYALLKGY 245 NC_006577_CoV-HKU1A_N1_nsp1_20 ------SDLIISNFKFDDYDFSVEDAYAEVHAEPKGKYS-QKAYALLRQY 220 AY884001_CoV-HKU1B_N2_nsp1_200 ------SDLIISNFKFDDYDFSVEDAYAEVHAEPKGKYS-QKAYALLRQY 220 DQ339101_CoV-HKU1C_N5_nsp1_200 ------SDLIISNFKFDDYDFSVEAAYAEVHAEPKGKYS-QKAYALLRQY 220 NC_004718_SARS-human_Tor2_nsp1 NKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTREL 177 AY545919_SARS-badger_CFB/SZ/94 NKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTREL 177 AY304488_SARS-civet_SZ16_nsp1_ NKGAGGHSYGTDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTREL 177 NC_009694_SARS-bat_HKU3-1_nsp1 NKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTREL 177 NC_009019_Bat-CoV-HKU4_B04f --GLGGQLFRE--RPWDRKETPYVEILDDLEADPTGKYS----QNLLKKL 192 NC_009020_Bat-CoV-HKU5_LMH3f --GFGGNRFRD--APWDYNWTPYSDLMDALEADPCGKYS----QSLLKKL 192 NC_002645_HCoV-229E_inf-1_nsp1 GG------------------------------------------------ 111 NC_005831_HCoV-NL63_AmsterdamI AG------------------------------------------------ 110 NC_003436_PEDV_CV777_nsp1_297. G------------------------------------------------- 110 NC_009657_BtCoV-G1_BtCoV/512/2 G------------------------------------------------- 110 EF203064_Bat-CoV-HKU2_HKU2/GD/ G------------------------------------------------- 110 NC_002306_TGEV_PUR46-MAD_nsp1_ -------------------------------------------------- DQ811787_PRCV_ISU-1_nsp1_304.. -------------------------------------------------- AY994055_FIPV_79-1146_nsp1_311 NG------------------------------------------------ 110 NC_009021_Bat-CoV-HKU9_BF_005I ---IGANSPPDVLPLWDGFSDPGPDVGPYLDFPDN------CCPTKPKAK 172 EF424621_AntelopeCoV_US/OH1/20 RG- 246 EF424622_GiCoV_US/OH3-TC/2006_ RG- 246 NC_003045_BCoV_BCoV-ENT_nsp1_2 RG- 246 NC_007732_PHEV_VW572_nsp1_211. RG- 246 NC_005147_HCoV-OC43_OC43_nsp1_ RG- 246 NC_001846_MHV_MHV-A59_nsp1_210 RG- 247 NC_006577_CoV-HKU1A_N1_nsp1_20 RG- 222 AY884001_CoV-HKU1B_N2_nsp1_200 RG- 222 DQ339101_CoV-HKU1C_N5_nsp1_200 RG- 222 NC_004718_SARS-human_Tor2_nsp1 NGG 180 AY545919_SARS-badger_CFB/SZ/94 NGG 180 AY304488_SARS-civet_SZ16_nsp1_ NGG 180 NC_009694_SARS-bat_HKU3-1_nsp1 NGG 180 NC_009019_Bat-CoV-HKU4_B04f IGG 195 NC_009020_Bat-CoV-HKU5_LMH3f VGG 195 NC_002645_HCoV-229E_inf-1_nsp1 --- NC_005831_HCoV-NL63_AmsterdamI --- NC_003436_PEDV_CV777_nsp1_297. --- NC_009657_BtCoV-G1_BtCoV/512/2 --- EF203064_Bat-CoV-HKU2_HKU2/GD/ --- NC_002306_TGEV_PUR46-MAD_nsp1_ --- DQ811787_PRCV_ISU-1_nsp1_304.. --- AY994055_FIPV_79-1146_nsp1_311 --- NC_009021_Bat-CoV-HKU9_BF_005I RGG 175